Azelaic acid emulsion 10 skin#
Isopropyl myristate is a polar emollient and potent skin enhancer that is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.
Hence, O/W microemulsions were examined as a drug carrier in this study to simultaneously enhance solubilization and skin permeability of azelaic acid. Since the continuous phase is water, the formulation is less oily and easy to be removed from the applied sites. Oil in water (O/W) microemulsions can be spontaneously formed by “solubilizing” oil molecules with a mixture of surfactants, cosurfactants, and cosolvents. The composition is simple, consisting of only the oil phase, surfactant, cosurfactant and water phase, and can be easily prepared via mild stirring. Microemulsion is a promising nanocarrier for the topical application of insoluble therapeutic compounds. Therefore, choosing appropriate excipients and ingredients is a crucial step in the design of appropriate formulations. In the pharmaceutical industry, the choice of an appropriate dosage form not only depends on the therapeutic effect but also many other factors, including the manufacturing process, cost, and patient attractiveness and compliance. Due to its low-water solubility, about 0.24 g/100 mL at 25 ☌, and limited penetration across the stratum corneum (SC), many formulations have been proposed, including microemulsion, liposome, gel, ethosome, liquid crystal and foam formulations, to increase the solubility and permeability of azelaic acid through the skin and to reduce the amount of drug used in the formulations. Since then, a 20% cream has also been approved for the treatment of acne. A 15% Azelaic acid gel was first approved on Decemfor the treatment of rosacea. Azelaic acid was thereby topically used for the treatment of acne and rosacea.
Azelaic acid emulsion 10 free#
Azelaic acid possesses anti-inflammatory properties, by its activity as a free oxygen radical scavenger, antibacterial effects against Staphylococcus epidermidis and Propionibacterium acnes, and keratolytic activity. In conclusion, the O/W microemulsion was a potential drug delivery carrier for azelaic acid topical application.Īzelaic acid (C 9H 16O 4, MW 188.22 g/mole, pKa values of 4.53 and 5.33) is a straight-chained dicarboxylic acid.
Moreover, the drug-loaded formulation also showed thermodynamic stability and chemical stability after storage for 30 days. The experimental formulation did not cause significant skin irritation compared to the negative control group. The edema index of ear swelling percentage was significantly recovered by the 5% drug-loaded formulation and a 20% commercial product, demonstrating that the experimental formulation possessed comparable effect with the commercial product on the improvement of inflammation. The permeability of azelaic acid was significantly increased by using O/W microemulsions as carriers. Skin irritation and stability tests were also performed. The permeability of azelaic acid through rat skin and the anti-inflammatory activities of the formulations were conducted to examine the efficacy of the designed formulations. Made with the highest-quality botanical, earth & marine-based ingredients combined with non-toxic-to-skin alternatives & advanced science.The aim of this study was to design oil in water (O/W) microemulsion formulations for the topical administration of azelaic acid. * CLEAN FORMULATION, NON-TOXIC: Cruelty free, paraben free, vegan, gluten free, fragrance free & non-toxic. * UNCLOG PORES, REFINE SKIN TEXTURE: Our topical acid formula helps unclog pores and balance excess sebum to minimize skin imperfections and even skin texture for smoother, more radiant skin. * POWERFUL, NON-IRRITATING FORMULA: Azelaic acid is a highly stable and effective topical acid that helps reduce redness and inflammation, as well as functioning as a safe and effective dark spot corrector. Perfect for those with sensitive, problematic skin. * ANTI-AGING, SKIN BRIGHTENING: This topical acid contains a high concentration of pure azelaic along with other skin brighteners to improve overall complexion.
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